Table 2.
Primary association of NCF1 rs201802880 among the GTF2I-NCF1 region SNPs demonstrated by conditional logistic regression analysis.
| rs73366469 | rs117026326 | rs80346167 | rs201802880 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| P | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | ||
| SLE all | before | 4.35 × 10−14 | 2.45 (1.95–3.10) | 6.82 × 10–16 | 2.67 (2.11–3.40) | 3.54 × 10−5 | 1.48 (1.23–1.79) | 3.77 × 10−44 | 3.57 (2.99–4.28) |
| SSc all | before | 0.014 | 1.45 (1.08–1.95) | 0.027 | 1.41 (1.04–1.92) | 0.047 | 1.28 (1.00–1.59) | 2.40 × 10−4 | 1.50 (1.21–1.87) |
| Adjusted by rs73366469 | |||||||||
| SLE all | after | — | — | 0.0018 | 2.31 (1.37–2.94) | 0.32 | 0.88 (0.69–1.13) | 5.11 × 10−34 | 3.41 (2.81–4.17) |
| SSc all | after | — | — | 0.86 | 1.06 (0.57–1.95) | 0.49 | 1.11 (0.82–1.49) | 0.0043 | 1.44 (1.12–1.84) |
| Adjusted by rs117026326 | |||||||||
| SLE all | after | 0.45 | 1.17 (0.70–1.96) | — | — | 0.24 | 0.87 (0.68–1.10) | 2.54 × 10−32 | 3.37 (2.77–4.14) |
| SSc all | after | 0.28 | 1.39 (0.76–2.50) | — | — | 0.35 | 1.15 (0.86–1.53) | 0.0029 | 1.47 (1.14–1.89) |
| Adjusted by rs80346167 | |||||||||
| SLE all | after | 5.50 × 10−11 | 2.69 (2.01–3.62) | 6.56 × 10−13 | 2.96 (2.21–4.00) | — | — | 1.63 × 10−41 | 3.53 (2.95–4.25) |
| SSc all | after | 0.12 | 1.34 (0.93–1.94) | 0.19 | 1.28 (0.89–1.85) | — | — | 9.84 × 10−4 | 1.46 (1.16–1.82) |
| Adjusted by rs201802880 | |||||||||
| SLE all | after | 0.29 | 1.15 (0.88–1.51) | 0.24 | 1.18 (0.89–1.56) | 0.56 | 1.06 (0.87–1.30) | — | — |
| SSc all | after | 0.45 | 1.14 (0.81–1.60) | 0.74 | 1.06 (0.74–1.52) | 0.25 | 1.16 (0.90–1.48) | — | — |
Conditional logistic regression analysis was performed under the additive model using R software. P values (P) and odds ratios (OR) were adjusted for sex. P and OR on rows “before” are before adjustment by any other SNPs. P and OR on rows “after” are adjusted by each SNP. In this table, P values are not adjusted for multiple testing. CI; confidence interval.