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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Med Phys. 2019 Sep 23;46(11):5075–5085. doi: 10.1002/mp.13808

Table 3.

Distribution of reproducibility groups of peritumoral radiomic features extracted from region-of-interests that are bounded by a lung mask.

Distancea
0 – 3 mm 0 – 6 mm 0 – 9 mm 0 – 12 mm P- Valueb
All features
CCC < 0.75 (Red) 68 (25.8) 55 (20.8) 71 (26.9) 80 (30.3)
CCC ≥ 0.75 & CCC ≤ 0.95 (Yellow) 121 (45.8) 148 (56.1) 138 (52.3) 113 (42.8)
CCC > 0.95 (Green) 75 (28.4) 61 (23.1) 55 (20.8) 71 (26.9) <0.001
P-Value 0.068 0.263 0.081
Statistical features
CCC < 0.75 (Red) 3 (15.8) 2 (10.5) 3 (15.8) 3 (15.8)
CCC ≥ 0.75 & CCC ≤ 0.95 (Yellow) 1 (5.3) 5 (26.3) 4 (21.0) 4 (21.0)
CCC > 0.95 (Green) 15 (78.9) 12 (63.2) 12 (63.2) 12 (63.2) 0.731
P-Value 0.272 1.000 1.000
Histogram features
CCC < 0.75 (Red) 5 (17.9) 2 (7.1) 4 (14.3) 4 (14.3)
CCC ≥ 0.75 & CCC ≤ 0.95 (Yellow) 7 (25.0) 15 (53.6) 10 (35.7) 10 (35.7)
CCC > 0.95 (Green) 16 (57.1) 11 (39.3) 14 (50.0) 14 (50.0) 0.512
P-Value 0.086 0.467 1.000
Texturec features
CCC < 0.75 (Red) 3 (4.8) 0 (0) 0 (0) 1 (1.6)
CCC ≥ 0.75 & CCC ≤ 0.95 (Yellow) 28 (45.2) 39 (62.9) 33 (53.2) 31 (50.0)
CCC > 0.95 (Green) 31 (50.0) 23 (37.1) 29 (46.8) 30 (48.4) 0.198
P-Value 0.038 0.363 0.857
3D Laws features
CCC < 0.75 (Red) 44 (35.2) 44 (35.2) 44 (35.2) 68 (54.4)
CCC ≥ 0.75 & CCC ≤ 0.95 (Yellow) 79 (63.2) 81 (64.8) 81 (64.8) 57 (45.6)
CCC > 0.95 (Green) 2 (1.6) 0 (0) 0 (0) 0 (0) 0.002
P-Value 0.615 1.000 0.003
Wavelet features
CCC < 0.75 (Red) 13 (43.3) 7 (23.3) 20 (66.7) 4 (13.3)
CCC ≥ 0.75 & CCC ≤ 0.95 (Yellow) 6 (20.0) 8 (26.7) 10 (33.3) 11 (36.7)
CCC > 0.95 (Green) 11 (36.7) 15 (50.0) 0 (0) 15 (50.0) <0.001
P-Value 0.305 <0.001 <0.001

Numbers inside parenthesis are the percentage values.

a

P-values were generated using Fisher’s Exact test comparing 0–3 mm vs. 0–6 mm, 0–6mm vs. 0–9 mm, and 0–9 mm vs. 0–12 mm, respectively.

b

P-value was generated using Fisher’s Exact test for the overall distributions of the four peritumoral distance (3 × 4 contingency table).

c

Features consist GLCM, GLRLM, GLSZM and NGTDM texture features.