Table 2.
Regression coefficients for associations of maternal 2nd trimester blood lead levels with BRIEF scores in mid-childhood (n=1006)
| Model 1a β (95% CI) |
Model 2b β (95% CI) |
|
|---|---|---|
| Parent-rated BRIEF Scales | ||
| Behavioral Regulation Index | 0.63 (−0.16, 1.42) | 0.69 (−0.13, 1.51) |
| Emotional control | 0.50 (−0.24, 1.24) | 0.58 (−0.18, 1.34) |
| Shift | 0.79 (−0.03, 1.61) | 0.88 (0.01, 1.75) |
| Inhibit | 0.42 (−0.39, 1.24) | 0.42 (−0.44, 1.28) |
| Metacognition Index | 0.64 (−0.07, 1.34) | 0.57 (−0.15, 1.29) |
| Initiate | 0.37 (−0.35, 1.09) | 0.31 (−0.44, 1.06) |
| Working memory | 0.64 (−0.13, 1.41) | 0.47 (−0.33, 1.27) |
| Plan/organize | 0.91 (0.20, 1.62) | 0.85 (0.12, 1.59) |
| Organization of materials | 0.21 (−0.50, 0.91) | 0.27 (−0.44, 0.98) |
| Monitor | 0.53 (−0.22, 1.28) | 0.49 (−0.29, 1.26) |
| General Executive Composite | 0.75 (−0.02,1.52) | 0.73 (−0.06, 1.52) |
| Teacher-rated BRIEF Scales | ||
| Behavioral Regulation Index | 0.41 (−0.41, 1.21) | 0.46 (−0.34, 1.26) |
| Emotional control | 0.50 (−0.38, 1.39) | 0.53 (−0.34, 1.41) |
| Shift | 0.22 (−0.67, 1.12) | 0.34 (−0.56, 1.23) |
| Inhibit | 0.37 (−0.39, 1.12) | 0.38 (−0.39, 1.14) |
| Metacognition Index | 0.37 (−0.48, 1.22) | 0.41(−0.43, 1.25) |
| Initiate | −0.002 (−0.81, 0.80) | −0.01 (−0.81, 0.79) |
| Working memory | −0.17 (−1.12, 0.79) | −0.16 (−1.11, 0.78) |
| Plan/organize | 0.61 (−0.30, 1.51) | 0.67 (−0.22, 1.57) |
| Organization of materials | 0.77 (−0.06, 1.61) | 0.82 (−0.03, 1.68) |
| Monitor | 0.44 (−0.43, 1.31) | 0.49 (−0.38, 1.35) |
| General Executive Composite | 0.37 (−0.45, 1.20) | 0.42 (−0.39, 1.23) |
Note: Coefficients represent change in score for an IQR increase in maternal erythrocyte lead (0.6 μg/dL).
a
Model 1: Outcomes standardized for child age and sex.
b
Model 2: Model 1 additionally adjusted for maternal 2nd trimester mercury and manganese levels, nulliparity, smoking during pregnancy, IQ, and education; paternal education; HOME composite score and household income; and child race/ethnicity.