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. Author manuscript; available in PMC: 2020 Feb 13.
Published in final edited form as: Oncogene. 2019 Aug 13;38(45):7060–7072. doi: 10.1038/s41388-019-0947-7

Figure 1. Detection of 10 AR backsplice junctions in mCRPC specimens.

Figure 1.

(A) Schematic diagram showing the pipeline for exome-capture RNA-seq, ribodepletion-seq, and RNase R-seq as well as subsequent backsplice junction identification. (B) Schematic diagram of 10 AR backsplice junctions that have more than four reads in at least one of the mCRPC samples in the SU2C cohort. The presumed circRNAs corresponding to these 10 backsplice junctions were named according to the exons bearing the splice donor and acceptor sites. (C) Read counts for each of the 10 AR backsplice junctions in the 47 mCRPC samples from the SU2C cohort. Error bars, mean with SEM. polyA, polyA RNA; circ, circRNA, lnc, long noncoding RNA; snc, small noncoding RNA; ribo, ribosomal RNA.