Table 1.

Genes exhibiting significant (FDR-adjusted P-value < 0.005) opioid-induced hyperalgesia treatment-by-central nervous system region interaction effect.

Gene Symbol	P-value	aFDR P- value	bOIH NA- CON NA	OIH TG- CON TG	CON TG- CON NA	OIH TG- OIH NA	OIH TG- CON NA	CON TG- OIH NA
Tusc5	1.7E−14	3.9E−10	−1.33	0.04	8.02	9.41	8.09	9.36
Lnpep	4.2E−14	4.9E−10	−0.13	1.35	1.44	2.95	2.82	1.58
Pirt	7.0E−12	5.4E−08	−0.96	−0.01	8.10	9.07	8.12	9.06
Itgb4	1.5E−10	8.7E−07	−0.36	0.15	2.84	3.37	3.01	3.21
Serpinb1a	4.1E−10	1.9E−06	−0.59	−0.03	2.91	3.49	2.90	3.51
Gm33320	6.4E−10	2.5E−06	0.31	−0.33	1.78	1.15	1.47	1.47
Acpp	7.9E−10	2.6E−06	−1.14	0.05	8.10	9.31	8.17	9.25
Scn7a	2.5E−09	7.4E−06	−0.94	0.17	7.25	8.38	7.44	8.20
Cysltr2	6.4E−09	1.6E−05	−1.31	−0.08	2.69	3.94	2.64	4.01
Gm33449	6.9E−09	1.6E−05	0.63	−1.51	0.60	−1.52	−0.88	−0.03
Aebp1	1.2E−08	2.5E−05	−0.50	0.54	1.81	2.86	2.37	2.31
Prelp	2.2E−08	4.3E−05	−0.64	0.02	0.53	1.21	0.57	1.18
Cldn19	2.9E−08	5.3E−05	−1.28	0.13	7.70	9.16	7.85	9.01
Pllp	3.2E−08	5.3E−05	−0.32	0.18	1.57	2.08	1.76	1.89
Arfgef3	6.3E−08	9.8E−05	−0.01	0.61	0.23	0.88	0.87	0.25
Mpz	1.0E−07	1.5E−04	−1.26	0.01	8.36	9.65	8.39	9.63
Myo1d	1.1E−07	1.5E−04	−0.24	0.20	1.73	2.19	1.96	1.98
Tlx2	1.8E−07	2.3E−04	−2.46	−0.03	8.32	10.77	8.31	10.78
Prx	2.4E−07	3.0E−04	−0.80	0.10	7.79	8.70	7.90	8.59
Zbed6	4.3E−07	5.0E−04	0.17	1.58	−0.35	1.08	1.25	−0.51
Avil	5.2E−07	5.7E−04	−0.92	−0.03	8.03	8.94	8.02	8.96
Sncg	5.6E−07	5.9E−04	−1.27	−0.07	7.63	8.84	7.58	8.90
Tmem233	7.9E−07	8.0E−04	−1.62	−0.01	8.48	10.09	8.49	10.09
Ppp1r1c	8.4E−07	8.2E−04	−0.88	0.00	7.97	8.87	7.99	8.86
BC005561	9.7E−07	9.1E−04	0.12	0.93	0.12	0.96	1.08	0.01
Gm42411	1.4E−06	1.3E−03	−0.08	1.25	−6.92	−5.53	−5.62	−6.85
Pmp22	2.9E−06	2.5E−03	−0.55	0.03	6.76	7.36	6.81	7.32
Lmbrd2	3.6E−06	3.0E−03	0.03	0.57	0.26	0.82	0.85	0.24
A2m	4.4E−06	3.5E−03	−0.79	0.00	4.57	5.38	4.59	5.37
Dok6	4.9E−06	3.7E−03	−0.17	1.05	−1.50	−0.26	−0.43	−1.32
Slc22a8	4.9E−06	3.7E−03	−0.14	0.91	−1.39	−0.32	−0.45	−1.24
Dbp	5.3E−06	3.9E−03	0.45	1.15	−2.48	−1.76	−1.31	−2.93
Apln	6.3E−06	4.4E−03	−0.52	0.26	−3.45	−2.65	−3.17	−2.93
Prrxl1	7.0E−06	4.8E−03	−0.70	0.06	7.60	8.39	7.68	8.32
Ahnak2	7.2E−06	4.8E−03	−0.95	0.08	8.09	9.14	8.19	9.04

^aFalse Discovery rate adjusted P-value.

^bLog2(fold change) between two treatment-brain region groups: OIH= opioid-induced hyperalgesia mice; CON=Control mice; TG=trigeminal ganglia; and NA=nucleus accumbens.