Table 5.
Clusters of enriched functional categories (enrichment score ES > 1.7) among the genes differentially expressed between the trigeminal ganglia and nucleus accumbens identified using DAVID.
| aCategory | Category Identifier and Name | P-value |
bFDR P- value |
|---|---|---|---|
| Cluster 1 | ES=3.89 | ||
| KEGG | mmu04512:ECM-receptor interaction | 1.2E−05 | 1.5E−02 |
| KEGG | mmu04510:Focal adhesion | 3.7E−05 | 4.8E−02 |
| Cluster 2 | ES=2.89 | ||
| BP | GO:0006813~potassium ion transport | 1.7E−05 | 3.0E−02 |
| MF | GO:0005244~voltage-gated ion channel activity | 1.2E−04 | 1.8E−01 |
| BP | GO:0034765~regulation of ion transmembrane transport | 1.3E−04 | 2.3E−01 |
| Cluster 3 | ES=2.89 | ||
| MF | GO:0004970~ionotropic glutamate receptor activity | 6.2E−04 | 9.6E−01 |
| MF | GO:0005234~extracellular-glutamate-gated ion channel activity | 6.2E−04 | 9.6E−01 |
| Cluster 4 | ES=2.35 | ||
| KEGG | mmu04015:Rap1 signaling pathway | 4.8E−04 | 6.2E−01 |
| Cluster 5 | ES=2.03 | ||
| KEGG | mmu05033:Nicotine addiction | 1.8E−04 | 2.3E−01 |
| Cluster 6 | ES=1.79 | ||
| KEGG | mmu04713:Circadian entrainment | 2.0E−06 | 2.6E−03 |
| KEGG | mmu04724:Glutamatergic synapse | 3.9E−06 | 5.1E−03 |
| KEGG | mmu04720:Long-term potentiation | 6.7E−05 | 8.6E−02 |
| KEGG | mmu05031:Amphetamine addiction | 3.7E−04 | 4.7E−01 |
| KEGG | mmu04911: Insulin secretion | 7.3E−04 | 9.4E−01 |
a
BP: biological process; MF: molecular function; KEGG: KEGG pathway.
b
False Discovery Rate adjusted P-value.