Table 1.

Binding potentials and ANOVA results for individual Regions of Interest

Region of Interest	1.Binding Potentiala	2.MAOA*flx p valueb	3.low-MAOA flx effect p valuec	4.low-MAOA flx effect sized
CORTEX
Dorsal Frontal Cortex	0.19	0.0032	0.0048	3.23
Enterorhinal/Piriform Cortex	0.21	0.3461	0.6822	ns
Posterior Cingulate/Precuneus	0.21	0.0101	0.0107	2.51
Visual Cortex	0.22	0.0618	0.0594	ns
Parietal Cortex	0.24	0.0101	0.0091	2.32
Orbital Frontal Cortex	0.24	0.0101	0.0107	3.64
Cingulate Cortex	0.26	0.0016	0.0032	3.65
Temporal Cortex	0.29	0.0142	0.0294	2.51
SUBCORTEX
Hippocampus	0.31	0.2430	0.2763	ns
Caudate Nucleus	0.46	0.0101	0.0107	2.62
Amygdala	0.60	0.3185	0.2785	ns
Insular Cortex	0.66	0.0130	0.0149	2.36
Hindbrain/Ventral Brainstem	0.72	0.1093	0.1781	ns
Putamen	0.74	0.0236	0.0594	ns
Thalamus	0.92	0.0716	0.0644	ns
Midbrain/Dorsal Brainstem	1.26	0.0957	0.0925	ns

^aROIs were averaged on left and right side of brain; the mean of left and right averages was then computed

^bInteraction term from 2-way ANOVA, least squares model, FDR corrected

^cPairwise comparison of fluoxetine and control within the low-MAOA subgroup; FDR correction

^dCohen’s D effect size for fluoxetine effect within the low-MAOA subgroup; ns=not significant (p value ≤0.01 for significance)