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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Neuropharmacology. 2019 Sep 2;160:107756. doi: 10.1016/j.neuropharm.2019.107756

Figure 2. Sex differences in precipitated but not spontaneous nicotine withdrawal.

Figure 2.

Rats were prepared with minipumps that contained nicotine or saline and the effects of mecamylamine-precipitated and spontaneous withdrawal on brain reward thresholds (A, C) and response latencies (B, D) were investigated. A, B) Asterisks indicate significantly different compared to rats of the same sex that received saline pumps and were treated with the same dose of mecamylamine. Plus signs indicate significantly different from rats in the same group (sex and pump content) and treated with vehicle (0 mecamylamine). C) Asterisks indicate significantly different from rats of the same sex and prepared with saline pumps. * p<0.05, ** ++ P<0.01. N=8–10/group. Data are expressed as means ± SEM.