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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Neuropharmacology. 2019 Sep 2;160:107756. doi: 10.1016/j.neuropharm.2019.107756

Figure 4. Decreased locomotor activity in the elevated plus maze in males and females after chronic nicotine administration.

Figure 4.

Rats were exposed to nicotine or saline for 14 days and tested on the elevated plus maze 4 days after removing the minipumps. Total distance traveled (A), the number of open arm entries (B), percentage open arm entries (C), and percentage time in open arms (D) were determined. Asterisks indicated a higher percentage of time on the open arms compared to male rats treated with saline. * p<0.05. N=8–10/group. Data are expressed as means ± SEM.