Table 5.
Stratification of Disease-Control (Disease-free vs. Recurrence/Metastasis). Analysis with Kruskal-Wallis H-Test. Values given as Mean Rank
| QLQ-C30 | No RT, Disease-free | No RT, Recurrence / Metastasis | Neoadj. RT, Disease-free | Neoadj. RT, Recurrence / Metastasis | H- and, p-value |
| Global QoL score | 42.96 | 42.33 | 30.10 | 25.88 |
H (3) = 7.572 p = 0.056 |
| Physical function score | 44.92 | 44.33 | 26.94 | 27.50 |
H (3) = 13.787 p = 0.003* |
| Pairwise comparison | H- and p-value | ||||
| Neoadj. RT + Disease-free vs. No RT + Disease free | H = 17.979, p = 0.003* | ||||
| Neoadj. RT + Disease-free vs. Neoadj. RT + Recurrence/Metastasis | H = 0.559, p = 1.00 | ||||
| Neoadj. RT + Disease-free vs. No RT + Recurrence/Metastasis | H = 17.392, p = 0.28 | ||||
| Neoadj. RT + Recurrence/Metastasis vs. No RT + Recurrence/Metastasis | H = 16.833, p = 1.00 | ||||
| Neoadj. RT + Recurrence/Metastasis vs. No RT + Disease-free | H = 17.420, p = 0.616 | ||||
| No RT + Recurrence/Metastasis vs. No RT + Disease-free | H 0.587, p = 1.00 | ||||
| Role function score | 43.44 | 45.17 | 30.00 | 19.50 |
H (3) = 10.696 p = 0.01* |
| Pairwise comparison | H- and p-value | ||||
| Neoadj. RT + Disease-free vs. RT + Disease free | H = 13.440, p = 0,05* | ||||
| Neoadj. RT + Disease-free vs. Neoadj. RT + Recurrence/Metastasis | H = 10.500, p = 1.00 | ||||
| Neoadj. RT + Disease-free vs. No RT + Recurrence/Metastasis | H = 15.167, p = 0.50 | ||||
| Neoadj. RT + Recurrence/Metastasis vs. No RT + Recurrence/Metastasis | H 25.667, p = 0.27 | ||||
| Neoadj. RT + Recurrence/Metastasis vs. No RT + Disease-free | H = 23.940, p = 0.15 | ||||
| No RT + Recurrence/Metastasis vs. No RT + Disease-free | H = − 1.727, p = 1.00 | ||||
| Emotional function score | 40.88 | 44.92 | 31.73 | 20.75 |
H (3) = 6.468 p = 0.09 |
| Cognitive function score | 37.46 | 39.83 | 33.24 | 28.38 |
H (3) = 1.668 p = 0,64 |
| Social function score | 45.58 | 42.83 | 27.68 | 19.38 |
H (3) = 16.108 p = 0.001* |
| Pairwise comparison | H- and p-value | ||||
| Neoadj. RT + Disease-free vs. RT + Disease free | H = 17.904, p = 0.002* | ||||
| Neoadj. RT + Disease-free vs. Neoadj. RT + Recurrence/Metastasis | H = 8.301, p = 1.00 | ||||
| Neoadj. RT + Disease-free vs. No RT + Recurrence/Metastasis | H = 15.157, p = 0.45 | ||||
| Neoadj. RT + Recurrence/Metastasis vs. No RT + Recurrence/Metastasis | H = 23.458, p = 0.35 | ||||
| Neoadj. RT + Recurrence/Metastasis vs. No RT + Disease-free | H = 26.205, p = 0.06 | ||||
| No RT + Recurrence/Metastasis vs. No RT + Disease-free | H 2.747, p = 1.00 | ||||
| Fatigue score | 27.50 | 24.42 | 36.57 | 44.38 |
H (3) = 5.969 p = 0.11 |
| Pain score | 28.52 | 29.92 | 39.09 | 48.38 |
H (3) = 6.598 p = 0.08 |
| Insomnia score | 33.42 | 33.25 | 33.79 | 57.75 |
H (3) = 6.665 p = 0.08 |
| Appetite loss score | 35.20 | 31.00 | 36.03 | 31.00 |
H (3) = 1.589 p = 0.66 |
| Nausea and vomiting score | 34.72 | 37.67 | 34.09 | 40.50 |
H (3) = 2.020 p = 0.56 |
| Constipation score | 33.30 | 29.00 | 35.93 | 46.75 |
H (3) = 4.962 p = 0.17 |
| Diarrhoea score | 32.20 | 33.67 | 35.11 | 45.12 |
H (3) = 2.946 P = 0.40 |
| Dyspnea score | 29.50 | 33.50 | 36.16 | 61.75 |
H (3) = 13.168 p = 0.004* |
| Pairwise comparison | H- and p-value | ||||
| Neoadj. RT + Disease-free vs. RT + Disease free | H = −6.662, p = 0.78 | ||||
| Neoadj. RT + Disease-free vs. Neoadj. RT + Recurrence/Metastasis | H = −25.588, p = 0.02* | ||||
| Neoadj. RT + Disease-free vs. No RT + Recurrence/Metastasis | H = − 2.662, p = 1.00 | ||||
| Neoadj. RT + Recurrence/Metastasis vs. No RT + Recurrence/Metastasis | H = −28.250, p = 0.05* | ||||
| Neoadj. RT + Recurrence/Metastasis vs. No RT + Disease-free | H = − 32.250, p = 0.002* | ||||
| No RT + Recurrence/Metastasis vs. No RT + Disease-free | H = − 4.000, p = 1.00 | ||||
| Financial problems score | 28.42 | 30.83 | 39.21 | 46.62 |
H (3) = 7.567 p = 0.056 |
* statistically significant (p < 0.05). Pairwise Comparison using Mann Whitney U-Test after Bonferroni procedure