Table 2.

Performance of AUDIT-C and biochemical markers for detecting alcohol use disorder

	Alcohol use disorder*****
	Men (N = 58)						Women (N = 30)
	AUC (95% CI)	SEN (95% CI)	SPC (95% CI)	LR+	LR−	Accuracy (95% CI)	AUC (95% CI)	SEN (95% CI)	SPC (95% CI)	LR+	LR−	Accuracy (95% CI)
AST*	0.83 (0.74; 0.90)	87.9 (76.7; 95.0)	63.2 (46.0; 78.2)	2.39	0.19	0.77 (0.67; 0.85)	0.82 (0.73; 0.88)	76.7 (87.7; 90.1)	80.5 (69.9; 88.7)	3.94	0.29	0.79 (0.70; 0.86)
GGT*	0.85 (0.76; 0.91)	87.9 (76.7; 95.0)	63.2 (46.0; 78.2)	2.39	0.19	0.77 (0.67; 0.85)	0.81 (0.72; 0.88)	70.0 (50.6; 85.3)	83.1 (72.9; 90.7)	4.15	0.36	0.79 (0.71; 0.87)
CDT**	0.83 (0.74; 0.90)	81.0 (68.6; 90.1)	71.1 (54.1; 84.6)	2.80	0.27	0.76 (0.66; 0.84)	0.80 (0.71; 0.87)	70.0 (50.6; 85.3)	84.4 (74.4; 91.7)	4.49	0.36	0.79 (0.71; 0.87)
GGT–CDT***	0.86 (0.77; 0.92)	79.3 (66.6; 88.8)	76.3 (59.8; 88.6)	3.35	0.27	0.77 (0.67; 0.85)	0.86 (0.77; 0.92)	66.7 (47.2; 82.7)	93.5 (85.5; 97.9)	10.27	0.36	0.79 (0.71; 0.87)
AUDIT-C****	0.97 (0.91;0.99)	96.5 (88.1;99.6)	89.5 (75.2;97.1)	9.17	0.04	0.94 (0.87;0.98)	0.89 (0.81;0.94)	76.7 (57.7;90.1)	90.9 (82.2;96.3)	8.43	0.26	0.87 (0.79;0.93)

^*Cutoff points for AST and GGT are 40 U/L

^**Cutoff point for CDT – “all” group is 1.0%, “men” group is 1.0%, and “women” group is 0.8%

^***Cutoff point for GGT–CDT – “all” group is 2.9308, “men” group is 3.0737, and “women” group is 2.2183

^****Cutoff point for AUDIT-C – “all” group is score 4, “men” group is score 4, and “women” group is score 8. (The cutoff point was determined by ROC analyses in the sample)

^*****Alcohol use disorder (alcohol abuse or alcohol dependence in DSM-IV-TR)/reference population (not meet the substance use disorder criteria in DSM-IV-TR)

AST = aspartic acid transaminase; AUC = area under the curve; AUDIT-C = Alcohol Use Disorder Identification Test Consumption; CDT = carbohydrate-deficient transferrin; GGT = gamma-glutamyltransferase; LR = likelihood ratios; SEN = sensitivity; SPC = specificity