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. 2019 Nov 8;17:363. doi: 10.1186/s12967-019-2113-y

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Significant related genes and hallmarks pathways in ccRCC obtained by GSEA. a–h The most involved significant pathways included complement, coagulation, IL6/JAK/STAT3 signaling, inflammatory response, hypoxia, IL2/STAT5 signaling, allograft rejection and TNF-alpha signaling via NFKB. i Transcriptional expression profiles of a total of 100 significant genes with positive and negative correlation were performed in a heat map