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. 2019 Nov 6;7:e7913. doi: 10.7717/peerj.7913

Table 2. Main clinical treatment results and adverse events in somatostatin and terlipressin groups.

Somatostatin group (N = 41) Terlipressin group (N = 109) P value
Initial hemostasis (within 48 h) 40 (97.6%) 108 (99.1%) 0.473
Rebleeding
Very early rebleeding (49–120 h) 1 (2.5%) 1 (0.9%) 0.469
Early rebleeding (6–42 d) 4 (10.0%) 14 (13.0%) 0.781
–Sources of early rebleeding
Esophageal varices 3 (7.5%) 10 (9.3%) 1.000
EVL-induced ulcer 1 (2.5%) 4 (3.7%) 1.000
Gastric varices/PHG 0 (0.0%) 0 (0.0%) 1.000
Mortality at 6 wk 4 (9.8%) 14 (12.8%) 0.419
–Cause of death
EV bleeding 3 (2.8%) 7 (6.4%) 1.000
Liver failure 0 (0%) 3 (2.8%) 0.562
Bacterial peritonitis 1 (2.4%) 2 (1.8%) 1.000
Hepatorenal syndrome 0 (0%) 1 (0.9%) 1.000
Pneumonia 0 (0%) 1 (0.9%) 1.000
Blood transfusion (unit) 4.6 ± 5.7 4.0 ± 3.6 0.421
Hospital stay (day) 8.1 ± 2.8 8.9 ± 4.0 0.240
Probable adverse events 13 (31.7%) 36 (33.0%) 0.878
–Vasoactive agent-related
Chest tightness/pain 6 (14.6%) 23 (21.1%) 0.488
Hypertension (SBP >140 mmHg) 5 (12.2%) 26 (23.9%) 0.116
Abdominal pain 2 (4.9%) 12 (11.0%) 0.352
Arrhythmia 1 (2.4%) 4 (3.7%) 1.000
Hyponatremia (Na <125 mmol/L) 2 (4.9%) 18 (16.5%) 0.103
Lymphangitis 0 (0%) 6 (5.5%) 0.189
Renal failure (Cr >2 mg/dL) 4 (9.8%) 3 (2.8%) 0.089
Hyperglycemia (Glu >300 mg/dL) 2 (4.9%) 4 (3.7%) 0.665
Flush 1 (2.4%) 3 (2.8%) 1.000
–EVL-associated
Chest tightness/pain 6 (14.6%) 23 (21.1%) 0.488
Retrosternal pain 5 (12.2%) 18 (16.5%) 0.617
Dysphagia/odynophagia 1 (2.4%) 2 (1.8%) 1.000
Post-EVL ulcer 4 (9.8%) 13 (11.9%) 1.000
Esophageal stricture 0 (0%) 0 (0%) 1.000

Notes.

EV
esophageal varix
EVL
endoscopic variceal ligation
PHG
portal hypertensive gastropathy
SBP
systolic blood pressure