Table 2. Main clinical treatment results and adverse events in somatostatin and terlipressin groups.
| Somatostatin group (N = 41) | Terlipressin group (N = 109) | P value | |
|---|---|---|---|
| Initial hemostasis (within 48 h) | 40 (97.6%) | 108 (99.1%) | 0.473 |
| Rebleeding | |||
| Very early rebleeding (49–120 h) | 1 (2.5%) | 1 (0.9%) | 0.469 |
| Early rebleeding (6–42 d) | 4 (10.0%) | 14 (13.0%) | 0.781 |
| –Sources of early rebleeding | |||
| Esophageal varices | 3 (7.5%) | 10 (9.3%) | 1.000 |
| EVL-induced ulcer | 1 (2.5%) | 4 (3.7%) | 1.000 |
| Gastric varices/PHG | 0 (0.0%) | 0 (0.0%) | 1.000 |
| Mortality at 6 wk | 4 (9.8%) | 14 (12.8%) | 0.419 |
| –Cause of death | |||
| EV bleeding | 3 (2.8%) | 7 (6.4%) | 1.000 |
| Liver failure | 0 (0%) | 3 (2.8%) | 0.562 |
| Bacterial peritonitis | 1 (2.4%) | 2 (1.8%) | 1.000 |
| Hepatorenal syndrome | 0 (0%) | 1 (0.9%) | 1.000 |
| Pneumonia | 0 (0%) | 1 (0.9%) | 1.000 |
| Blood transfusion (unit) | 4.6 ± 5.7 | 4.0 ± 3.6 | 0.421 |
| Hospital stay (day) | 8.1 ± 2.8 | 8.9 ± 4.0 | 0.240 |
| Probable adverse events | 13 (31.7%) | 36 (33.0%) | 0.878 |
| –Vasoactive agent-related | |||
| Chest tightness/pain | 6 (14.6%) | 23 (21.1%) | 0.488 |
| Hypertension (SBP >140 mmHg) | 5 (12.2%) | 26 (23.9%) | 0.116 |
| Abdominal pain | 2 (4.9%) | 12 (11.0%) | 0.352 |
| Arrhythmia | 1 (2.4%) | 4 (3.7%) | 1.000 |
| Hyponatremia (Na <125 mmol/L) | 2 (4.9%) | 18 (16.5%) | 0.103 |
| Lymphangitis | 0 (0%) | 6 (5.5%) | 0.189 |
| Renal failure (Cr >2 mg/dL) | 4 (9.8%) | 3 (2.8%) | 0.089 |
| Hyperglycemia (Glu >300 mg/dL) | 2 (4.9%) | 4 (3.7%) | 0.665 |
| Flush | 1 (2.4%) | 3 (2.8%) | 1.000 |
| –EVL-associated | |||
| Chest tightness/pain | 6 (14.6%) | 23 (21.1%) | 0.488 |
| Retrosternal pain | 5 (12.2%) | 18 (16.5%) | 0.617 |
| Dysphagia/odynophagia | 1 (2.4%) | 2 (1.8%) | 1.000 |
| Post-EVL ulcer | 4 (9.8%) | 13 (11.9%) | 1.000 |
| Esophageal stricture | 0 (0%) | 0 (0%) | 1.000 |
Notes.
- EV
- esophageal varix
- EVL
- endoscopic variceal ligation
- PHG
- portal hypertensive gastropathy
- SBP
- systolic blood pressure