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. 2019 Nov 5;12:9177–9187. doi: 10.2147/OTT.S222836

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© 2019 Chang et al.

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The expression and clinical significance of miR-769-5p in glioma. (A) The expressions of miR-769-5p were examined by qRT-PCR in 60 paired glioma tissues and adjacent nontumor tissues. (B) The levels of miR-769-5p were determined by qRT-PCR in four glioma cell lines (A172, T98, U87 and U251) and a normal human astrocyte (NHA) cell line. (C) Glioma patients with high WHO grades had significantly higher levels of miR-769-5p compared to cases with low WHO grades. (D) The expression of miR-769-5p in glioma tissues with different WHO grades base CGGA database. (E) Glioma patients highly expressing miR-769-5p showed an obvious poorer survival compared to cases with low miR-769-5p expression. (F) CGGA data indicated that high miR-769-5p expression indicated poor prognosis of glioma. *P<0.05, **P<0.01.