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. Author manuscript; available in PMC: 2019 Nov 9.
Published in final edited form as: Curr Genet. 2018 Feb 22;64(5):965–970. doi: 10.1007/s00294-018-0817-9

Fig. 3. Interaction of Tel2 with PIKKs through the HEAT repeat domain.

Fig. 3.

The kinase domains (KDs) of PIKKs are located near C-termini and are flanked by the conserved FRAP-ATM-TRRAP (FAT) and FAT C-terminal (FATC) domains [18]. Nterminal and internal regions of PIKKs contain numerous α-helical Huntington-elongation factor 3-A subunit of protein phosphatase 2A-TOR1 (HEAT) repeats [21]. Human Tel2 has been shown to interact with ATM and mTOR through the HEAT repeat regions.