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. Author manuscript; available in PMC: 2019 Nov 9.
Published in final edited form as: J Med Chem. 2018 Jun 29;61(13):5623–5642. doi: 10.1021/acs.jmedchem.8b00375

Figure 3.

Figure 3.

Representative hit fragments that bind to WDR5 at the MLL-site with putative arginine (S2) mimics in blue. Ki values were obtained by Fluorescence Polarization Assay.