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. 2019 Nov 5;12:9227–9237. doi: 10.2147/OTT.S217595

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© 2019 Yin et al.

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HGF/MET can induce invasion and migration of NSCLC cells by SNAI2. (A) Cell invasion of A549 and SK-MES-1 cells with or without HGF treatment (50 μg/L, 72 hrs) was detected by transwell-chamber culture systems. MET inhibitor (XL184, 10 μmol/L) can inhibit the regulating effect of exogenous HGF. HGF/MET regulated the invasion by SNAI2. Bar graphs show the number of invaded cells. (B) Cell migration of A549 and SK-MES-1 cells with or without HGF treatment (50 μg/L, 72 hrs) was detected by the scratch assay. MET inhibitor (XL184, 10 μmol/L) can inhibit the regulating effect of exogenous HGF. HGF/MET regulated the migration by SNAI2. (n=3, *P < 0.05).