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. 2019 Nov 5;12:9227–9237. doi: 10.2147/OTT.S217595

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© 2019 Yin et al.

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HGF/MET regulated SNAI2 expression by FOSL2. (A) Expressions of JUN, JUNB, JUND, FOS, FOSB, FOSL1 and FOSL2 in A549 and SK-MES-1 cells with or without exogenous HGF treatment (50 μg/L, 72 hrs) were measured by RT-PCR. MET inhibitor (XL184, 10 μmol/L) can inhibit the regulating effect of exogenous HGF. (B) FOSL2 signal in the SNAI2 promoter region was detected by chromatin immunoprecipitation (ChIP) assay. (C) The transcriptional activation of SNAI2 by FOSL2 was detected by luciferase assays. (D) HGF/MET regulated the expression of SNAI2 by FOSL2 in A549 and SK-MES-1 cells. (n=3, *P < 0.05).