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. 2019 Nov 5;12:9227–9237. doi: 10.2147/OTT.S217595

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© 2019 Yin et al.

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HGF/MET induced upregulation and phosphorylation of FOSL2 by activating ERK1/2. (A) The effect of PI3K inhibitor (LY294002, 20 μmol/L), ERK1/2 inhibitor (U0126, 10 μmol/L) and p38 MAPK inhibitor (SB203580, 20 μmol/L) on HGF induced upregulation of FOSL2 in A549 and SK-MES-1 cells. (B) HGF/MET regulated upregulation and phosphorylation of FOSL2 by activating ERK1/2. (C) HGF/MET regulated the upregulation of FOSL2 by ERK1/2 in A549 and SK-MES-1 cells. (D) Time series analysis of HGF/MET regulating ERK1/2, FOSL2 and SNAI2. (n=3, *P < 0.05).