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. 2019 Nov 5;12:8935–8945. doi: 10.2147/OTT.S210739

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© 2019 Xue et al.

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MiR-139-3p inhibits SK-OV-3 cell proliferation and tumor growth in nude mice. (A) qRT-PCR analysis of miR-139-3p expression in miR-139-3p or miR-NC-transfected SK-OV-3 and OVCAR3 cells. (B) CCK8 assay showing cell proliferation rates of miR-139-3p-transfected SK-OV-3 or OVCAR3 cells. (C) Estimation of colonies in SK-OV-3 or OVCAR3 cells stable expressing miR-139-3p. **P<0.01 compared to control. (D) Xenograft tumor volumes in nude mice injected with SK-OV-3 cells stable expressing miR-139-3p and miR-NC. Tumor volumes were measured every week until the fifth week when mice were sacrificed. (E) The weight of tumor tissue in each group was measured. (F) Representative images of xenograft tumors derived from SK-OV-3 cells stable expressing miR-139-3p and miR-NC. *P<0.05, **P<0.01 compared to miR-NC.