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. 2019 Nov 5;11:9353–9369. doi: 10.2147/CMAR.S219689

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© 2019 Li et al.

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MST4 expression was significantly upregulated in gastric cancer (GC). (A) The mRNA expression profile of MST4 in GCTs and ANGMs was analyzed by UALCAN program using TCGA data. GCT, GC tissue; ANGM, adjacent noncancerous gastric mucosa. (B) Expression of MST4 in TCGA database based on tumor stages. (C) Expression of MST4 in TCGA database based on tumor grade. (D) Expression of MST4 in TCGA database based on histological subtypes. (E) MST4 expression was significantly up-regulated in GCT. (E1) qRT-PCR was used to analyze MST4 mRNA expression in GCTs (n=50) and ANGMs (n=50). (E2) Western blot results showed that MST4 protein expression was higher in GCTs than in ANGMs. (F1 and F2) MST4 expression was significantly up-regulated in GC cell lines. (F1) Quantitative real-time PCR (qRT-PCR) analysis of MST4 mRNA showed, compared with normal gastric epithelial cell line GES-1, MST4 mRNA expression elevated in GC cell lines including AGS, SGC-7901, HGC27 and MKN45 cell line. (F2) Western blot results showed MST4 protein was overexpressed in AGS, SGC-7901, HGC27 and MKN45 cell line relative to GES-1 cell line. *P < 0.05; **P < 0.01; ***P < 0.001.