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. 2019 Nov 5;11:9353–9369. doi: 10.2147/CMAR.S219689

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© 2019 Li et al.

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MST4 promotes gastric cancer cells invasion and metastasis. (A1 and A2) Validation of the expression of MST4 in MKN45 and AGS cell line after transfection with knockdown (A1) and overexpression (A2) vectors, respectively. (B) Methyl thiazolyl tetrazolium (MTT) assay was performed to assess the effect of MST4 on GC cell proliferation. (C) Colony formation assay was used to determine the proliferation of GC cells. (D) MST4 promoted cell-ECM adhesion. (E) MST4 inhibited cell-cell adhesion. (F) Transwell migration assay showed MST4 promoted GC cell migration. (G) Transwell invasion assay showed MST4 promoted GC cell invasion. (H) Mice tail vein injection experiment showed MST4 significantly promoted the formation of pulmonary metastatic focuses. *P < 0.05; **P < 0.01; ***P < 0.001.