Table 7.

Cox Proportional Hazard Regression Analyses For DFS In The Validation Cohort

Parameters	Univariate Analysis	P	Multivariate Analysis	P
HR (95% CI)	HR (95% CI)
Gender (male vs female)	1.359 (0.831–2.221)	0.221	NA
Age (y, ≤60 vs >60)	1.088 (0.668–1.773)	0.734	NA
Tumor size (cm, >5 vs ≤5)	1.813 (1.002–3.280)	0.046	1.613 (0.990–2.627)	0.122
Grade of differentiation (poor and not vs well and moderate)	1.605 (0.983–2.618)	0.158	NA
Lauren’s classification (intestinal vs diffuse)	1.092 (0.929–1.284)	0.285	NA
Lymph node metastasis (positive vs negative)	2.907 (1.514–4.488)	<0.001	2.032 (1.409–2.930)	0.007
Lymphovascular invasion (positive vs negative)	1.932 (1.095–3.410)	0.010	1.795 (1.010–3.189)	0.033
TNM stage (III vs I & II)	2.580 (1.569–4.243)	0.001	1.902 (1.399–2.586)	0.016
MST4 expression (high vs low)	2.329 (1.357–3.997)	0.002	1.862 (1.211–2.863)	0.021

Abbreviations: DFS, disease-free survival; NA, not adopt; TNM, tumor node metastasis; MST4, mammalian sterile-20-like kinase 4.