Table 1.
Existing pediatric neuroimaging data collection and sharing initiatives
| Datasets currently available | Age Range (years) | Variables Collected | Strengths | Limitations | |
|---|---|---|---|---|---|
| Philadelphia Neurodevelopmental Cohort (PNC) | TD: 1,445 | 8–21 | Neuroimaging: sMRI, DWI, ASL, tfMRI, rsfMRI Other: Kiddie-SADS; Penn CNB | All data acquired on same scanner platform. Genotype available. | rsfMRI collected with relatively long TR (3000ms). |
| Adolescent Brain Cognitive Development (ABCD) | TD: 4,010 (inaugural data release) | 9–10 |
Neuroimaging: sMRI, DWI, tfMRI, rsfMRI Other: Kiddie-SADS and other clinical measures, NIH toolbox, physical, cultural, biological measures |
Uses harmonized HCP protocol. Genotype, longitudinal and sleep data will be available. | Data collection ongoing. Data collection on different scanner platforms. |
| Human Connectome Project (HCP) Lifespan Development | TD: 1,350 | 5–21 |
Neuroimaging: sMRI, multishell DWI, tfMRI, rsfMRI Other: extensive battery of social, behavioral, and neurocognitive measures |
Uses harmonized HCP protocol. rsfMRI collected with short TR (720ms). Genotype, sleep data, and pubertal status will be available. Longitudinal data available for subset. | Data collection ongoing. |
| IMAGEN | TD: > 2,000 | 14, follow up at 16, 19, 22 |
Neuroimaging: sMRI, DWI, tfMRI, rsfMRI Other: extensive battery of social, behavioral, and neurocognitive measures |
Longitudinal data collected at multiple timepoints will be available. Genotype and pubertal status available. Collaboration with ENIGMA. | Data collection on different scanner platforms. Recruitment emphasized ethnic homogeneity. |
| Autism Brain Imaging Data Exchange (ABIDE) I and II | ABIDE I ASD: 539, TD: 573 ABIDE II ASD: 521, TD: 593 |
5–64 |
Neuroimaging: sMRI, rsfMRI Other: some clinical assessments |
Wide age ranges available. Preprocessed neuroimaging data available. | Data collection on different scanner platforms. Limited phenotypic information. |
| ADHD-200 | ADHD: 285 TD: 491 |
7–21 |
Neuroimaging: sMRI, rsfMRI Other: some clinical assessments |
Wide age ranges available. | Data collection on different scanner platforms. Limited phenotypic information. |
| SchizConnect | Schizophrenia: 384 TD: 632 |
0–67 |
Neuroimaging: sMRI, tfMRI, rsfMRI Other: some clinical assessments |
Wide age ranges available. | Data collection on different scanner platforms. Phenotypic information varies by dataset. |
| NKI-Rockland | TD: > 1000 | 6–85 |
Neuroimaging: sMRI, DWI, tfMRI, rsfMRI Other: extensive battery of social, behavioral, and neurocognitive measures |
rsfMRI data collected at to different TRs (645 and 1400ms) available. All data acquired on same scanner platform. | Limited task fMRI data available. |
| Pediatric Imaging, Neurocognition, and Genetics (PING) | TD: > 1000 | 3–20 |
Neuroimaging: sMRI, DWI, rsfMRI Other: extensive battery of social, behavioral, and neurocognitive measures |
Genotype available. | Data collection on different scanner platforms. |
ASD = Autism Spectrum Disorder; ADHD = Attention-Deficit/Hyperactivity Disorder; TD = Typically Developing; sMRI = structural MRI; DWI = Diffusion Weighted Imaging; ASL = Arterial Spin Labeling; tfMRI = task fMRI; rsfMRI = resting state fMRI; Kiddie-SADS = Kiddie-Schedule for Affective Disorders and Schizophrenia; Penn CNB = Computerized Neurocognitive Battery; ENIGMA = Enhancing Neuro Imaging Genetics through Meta Analysis; TR = repetition time