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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Drug Discov Today. 2019 Jul 26;24(10):2002–2016. doi: 10.1016/j.drudis.2019.06.019

FIGURE 4.

FIGURE 4.

Graphical representations of the database search and affinity selection strategies used to identify small molecules interacting with RNA. (a) Inforna search reveals that Targapremir-210 (TGP-210) targets the Dicer site of miRNA-210 featuring a 1 × 1 CC internal loop; (b) A 214 375-member library on polymeric microbeads was spatially segregated allowing for spatial differentiation between cyclic γ-AA peptides (surface) and a corresponding linear tag (core). The beads were incubated with the fluorescently labeled oligonucleotide containing the UPF1-binding RNA sequence. Highly fluorescent beads were isolated, the linear tag was released from the beads, and its sequence deconvoluted via tandem mass spectrometry