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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Drug Discov Today. 2019 Jul 26;24(10):2002–2016. doi: 10.1016/j.drudis.2019.06.019

FIGURE 6.

FIGURE 6.

Graphical representation of emerging modalities that cleave disease-causing RNAs. (a) The dimeric molecule 2H-K4NMeS covalently linked with the nucleic acid cleavage moiety Bleomycin A5 efficiently cleaves r(CUG)exp. (b) The dimeric molecule Targaprimir-96 (TGP-96) covalently linked to the RNase L dimerization unit 2’−5’-A4 efficiently cleaves miRNA-96. This is achieved by the endogeneous nuclease activity of RNase L, which is placed in close proximity to miRNA-96 by the RNA-binding module TGP-96.