Table 3.
Association of active disease versus inactive disease on pregnancy outcomes among women with psoriatic arthritis (PsA) (n = 117) and AS (n = 129) in OTIS cohort 2004–2018
| PsA (N = 117) |
AS (N = 129) |
|||||||
|---|---|---|---|---|---|---|---|---|
| Active Disease by HAQb | Active Disease by RAPID3b | Active Disease by HAQb | Active Disease by RAPID3b | |||||
| At intake (n = 23) |
At 32 weeks (n = 26) |
At intake (n = 42) |
At 32 weeks (n = 27) |
At intake (n = 38) |
At 32 weeks (n = 41) |
At intake (n = 54) |
At 32 weeks (n = 46) |
|
| Preterm Delivery | ||||||||
| Number of events, n (%) | 3 (13.0) | 8 (30.8) | 8 (19.0) | 8 (29.6) | 5 (13.2) | 4 (9.8) | 7 (13.0) | 4 (8.7) |
| Adjusted Risk Ratioa (95% CI) | 0.73 (0.18–3.00) | 3.82 (1.51–9.67) | 1.60 (0.57–4.48) | 3.75 (1.20–11.67) | 1.81 (0.52–6.29) | 1.45 (0.38–5.49) | 1.63 (0.61–4.33) | 1.59 (0.43–5.93) |
| Preterm Labor | ||||||||
| Number of events, n (%) | 5 (21.7) | 8 (30.8) | 10 (23.8) | 8 (29.6) | 7 (18.9) | 3 (7.3) | 7 (13.2) | 4 (8.7) |
| Adjusted Risk Ratioa (95% CI) | 0.94 (0.32–2.73) | 2.97 (1.20–7.34) | 1.81 (0.73–4.50) | 3.24 (0.96–10.98) | 2.93 (0.87–9.91) | 1.63 (0.29–9.27) | 1.60 (0.51–5.02) | 5.82 (1.06–31.78) |
| Caesarian Delivery | ||||||||
| Number of events, n (%) | 10 (43.5) | 0.66 (0.37–1.19) | 19 (45.2) | 14 (51.9) | 18 (47.4) | 14 (34.1) | 26 (48.1) | 17 (37.0) |
| Adjusted Risk Ratioa (95% CI) | 16 (61.5) | 0.96 (0.64–1.44) | 0.99 (0.60–1.62) | 0.82 (0.54–1.23) | 1.38 (0.78–2.43) | 1.01 (0.54–1.88) | 1.97 (1.12–3.47) | 1.58 (0.87–2.87) |
| NICU Hospitalization | ||||||||
| Number of events, n (%) | 4 (17.4) | 1.16 (0.37–3.66) | 5 (11.9) | 4 (14.8) | 7 (18.9) | 9 (22.0) | 11 (20.8) | 8 (17.4) |
| Adjusted Risk Ratioa (95% CI) | 5 (19.2) | 2.01 (0.50–7.99) | 1.00 (0.28–3.48) | 1.40 (0.24–8.05) | 1.19 (0.49–2.91) | 1.97 (0.75–5.15) | 1.41 (0.66–2.99) | 0.96 (0.36–2.54) |
Multivariable adjusted risk ratio computed using Poisson regression with robust errors for: Maternal age, Race (white), SES (high), Pre-pregnancy BMI, Smoking, Parity, Pre-existing medical disease (HTN, thyroid disease, diabetes, asthma), and previous adverse pregnancy outcome (preeclampsia, preterm, IUGR)
Active disease defined by HAQ score > 0.5 and RAPID3 score ≥7 and inactive disease defined as HAQ score ≤0.5 and RAPID3 score ≤6; Disease activity measures missing for 14 subjects in PsA and 19 subjects in AS at intake and 34 subjects in PsA and 38 subjects in AS at 32 weeks. HAQ = health assessment questionnaire; RAPID3 = Routine Assessment of Patient Index Data 3.