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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Epilepsia. 2019 Oct 17;60(11):2277–2285. doi: 10.1111/epi.16371

Figure 2:

Figure 2:

Biophysical characterization of sodium channel variants in family 1. Representative traces of families of sodium channel currents recorded from ND7/23 cells expressing A. WT, B. G269R and C. T1360N. D. Averaged current-voltage (I-V) curves for WT (n = 37), G269R (n = 5) and T1360N (n = 7). E. Voltage dependence of channel activation. Example traces of steady state inactivation curves for WT (F) and T1360N (G). Inset shows voltage protocol for steady-state inactivation. H. Voltage dependence of steady-state inactivation for WT (n = 37) and T1360N (n = 7). Data represent means ± SEM. Smooth lines in E and H correspond to single Boltzmann equation fits to average data.