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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Epilepsia. 2019 Oct 17;60(11):2277–2285. doi: 10.1111/epi.16371

Figure 3.

Figure 3.

Biophysical characterization of sodium channel variants in family 2. Representative traces of families of sodium channel currents recorded from ND7/23 cells expressing A. WT, B. G822R and C. R1648C. D. Averaged current-voltage (I-V) curves for WT (n = 37), G822R (n = 9) and R1638C (n = 12). E. Voltage dependence of steady state inactivation for WT (n = 37) and R1638C (n = 12). Example traces of sodium currents recorded for WT (F) and R1648C (G) showing a reduction in current amplitude in R1648C cells compared with WT at a given activation voltage. Inset shows activation voltage protocol. H. Voltage dependence of activation for WT (n = 37) and R1638C (n = 12). Data represent means ± SEM. Smooth lines in E and H correspond to single Boltzmann equation fits to average data.