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. Author manuscript; available in PMC: 2020 Nov 1.

Published in final edited form as: Epilepsia. 2019 Oct 17;60(11):2277–2285. doi: 10.1111/epi.16371

TABLE 2.

Activation and Inactivation Parameters of wildtype and variant Na_v1.6 currents.

	Activation		Inactivation
	V_1/2 (mV)	k	V_1/2 (mV)	k

WT (n=37)	−25.8 ± 0.8	5.37 ± 0.22	−66.9 ± 0.9	7.75 ± 0.14
Family 1, allele 2 T1360N (n=7)	−26.0 ± 1.6	5.29 ± 0.47	−74.4 ± 1.6^**	7.79 ± 0.35
Family 2, allele 2 R1628C (n=12)	−22.0 ± 0.8^*	6.65 ± 0.29^**	−66.7 ± 2.0	10.4 ± 0.88^***

^*

p<0.05

^**

p<0.01

^***

p<0.001 compared to WT; unpaired t-test.