Fig. 1.

Cardiac diastolic function in 3- and 6-month-old offspring. Mean ± SEM echocardiographic indices of diastolic function in 3- and 6-month-old male (n = 7–9, a–c) and female (n = 6–10, d–f) offspring of control, phosphate-buffered saline (PBS)-infused pregnant mice (C/PBS) and obese pregnant mice infused either with PBS (Ob/PBS) or adiponectin (Ob/AND) from E14.5 to 18.5. y Axes represent dimensionless ratios of velocities (mm s⁻¹) of early-diastolic mitral inflow and ventricular wall displacement (E/E’), early- and late-diastolic ventricular wall displacement (E’/A’) and early- and late-diastolic mitral inflow (E/A). Overall effect of maternal treatment group, determined by one-way analysis of variance at each offspring age, given in figure. Values with different superscripts, a or b, are significantly different from one another by pairwise post hoc comparison (P < 0.05, Holm–Sidak test)