Fig. 3.
Gβγ subunit interactions with effector proteins. Gβ1 is shown in gray and Gγ2 in beige, with various effectors shown in different colors: Gαi1 is shown in green, GRK2 is shown in red, GIRK2 is shown in cyan, and the PTH receptor is shown in orange. These complexes show the various ways that Gβγ can engage with effectors. While Gα has a bivalent interaction with Gβγ, the other effectors illustrated here interact with Gβ at a single surface. These interaction interfaces differ between the binding partners. It is important to note that most of these effectors share interaction surfaces with Gα and, therefore, interact only with free Gβγ, apart from the PTH receptor C-terminal helix contacting the side of the Gβ toroid