Table 1.

Frequency of chromatin modifying and organizing gene mutations in B-cell and T-cell lymphomas. Data from genome, exome and transcriptome sequencing studies of FL [43, 113, 114, 116, 117, 119], BL [99, 120], DLBCL [34, 117, 118, 121, 122] and TCL [35, 123] with sufficient data quality are summarized.

Epigenetic modifers	Function	Mutation frequency				Mutation type	Protein activity	Histone state (as a consequence of mutations)
		FL, % [43, 114, 116]	GCB-like, %	BL, %	TCL, %
EZH2	H3K27 methyltransferase	25	15–20 [117]	2	ATLL, 3 CTCL, 0	Gain of function	active	H3K27me3 ↑
KMT2D	H3K4 methyltransferase	72	25 [118]	2	CTCL, 2	Loss of function	inactive	H3K4me1/me2↓
CREBBP	lysine acetyltransferase	65	32 [34]	6	CTCL, 5	Loss of function	inactive	H3K27ac ↓ H3K18ac ↓
EP300	lysine acetyltransferase	15	10 [34]	0	ATLL, 20 [35]	Loss of function	inactive	H3K27ac ↓ H3K18ac ↓
ARID1A	SWI/SNF component	11	10	7	CTCL, 5	Loss of function	inactive
SMARCA 4	SWI/SNF component	1	10	21	CTCL, 5	Loss of function	inactive
HIST1H1E	linker histone	14	17	0	0	Loss of function	inactive