Table 2.
Characteristic of all included patients
| Reference | Group | Age | Gleason score n, (≤6/7/≥8) | Pathologic T stage (n) | Preoperative PSA (ng/ml) | Pre-RT PSA (ng/ml) | PSM n (%) | Radiation dose (Gy) |
|---|---|---|---|---|---|---|---|---|
| Briganti 2012 | ART | Median (IQR):64 (60–68) | 160/185/45 | T3a:261 T3b:129 | Median(IQR): 10 (6.7–16.1) | Median(IQR): 0 (0–0) | 245 (62.8) | Median(IQR): 65 (60–70) |
| ESRT | Median (IQR):65 (61–69) | 163/173/54 | T3a:274 T3b:116 | Median(IQR): 10 (6.3–14.7) | Median(IQR): 0.2 (0.1–0.3) | 238 (61.0) | Median(IQR): 66 (66–66) | |
| Buscariollo 2017 | ART | Median (IQR):60 (54–65) | 31/83/56 |
T2:43 T3:128 |
Median(IQR): 6 (5–10) | < 0.1 | 143 (83.6) | Median(IQR): 61.2 (61.2, 64.8) |
| ESRT | Median (IQR):59 (54–63) | 43/142/45 |
T2:90 T3:140 |
Median(IQR): 6 (5–10) | Median(IQR): 0.3 (0.2–0.4) | 163 (70.9) | Median(IQR): 64.8 (64.8, 64.8) | |
| Fossati 2016 | ART | Median (IQR):64 (61–69) | 57/120/66 | T3a:137 ≥ T3b:106 | Median(IQR): 9.3 (6.2–15.8) | Median(IQR): 0 (0–0) | 181 (74) | Median(IQR): 60 (60–65) |
| ESRT | Median (IQR):65 (60–70) | 49/147/71 | T3a:168 ≥ T3b:99 | Median(IQR): 9.8 (6.3–14.8) | Median(IQR): 0.2 (0.1–0.3) | 138 (52) | Median(IQR): 67 (66–67) | |
| Hwang 2018 | ART | Median (IQR):60 (55–65) | 50/210/106 |
T2:98 T3:268 |
UC | < 0.1 | 313 (85.8) | Median(IQR): 64.8 (61.2–66.0) |
| ESRT | Median (IQR):61 (54.6–65.3) | 33/209/124 | T2:109 T3:257 | UC | Median(IQR): 0.3 (0.2–0.4) | 318 (86.9) | Median(IQR): 66.0 (64.8–70.0) | |
| Borghetti 2017 | ART | Overall median (range): 65 (42–78) | 24/60/43 | T2:20 ≥ T3:107 | UC | UC | 99 (78.0) | UC |
| SRT | 42/57/32 |
T2:50 ≥T3:81 |
UC | UC | 80 (61.1) | UC | ||
| Hervas 2017 | ART | Mean (range):62.7 (43.0–75.0) | 199(≤7)/20 | ≤T2:83 ≥ T3:124 | UC | ≤0.5 | 156 (70.9) | UC |
| SRT | Mean (range):64.8 (42.0–82.0) | 393(≤7)/47 | ≤T2:272 ≥ T3:172 | UC | UC | 214 (47.5) | UC | |
| Mishra 2015 | ART | Median:59 | 12/40/19 | UC | UC | Median:< 0.1 | 60 (81.1) | Median:66 |
| SRT | Median:63 | 22/49/33 | UC | UC | Median:0.6 | 86 (76.8) | Median:66.6 | |
| Hsu 2015 | ART | UC | 14/34/26 | ≤T2:12 ≥ T3:64 | UC | < 0.1 | 50 (79) | UC |
| SRT | UC | 22/118/83 | ≤T2:86 ≥ T3:143 | UC | Median(IQR): 0.5 (0.3–1.0) | 149 (86) | UC | |
| Tilki 2016 | ART | Median (IQR):65 (60–70) | 0/116/97 | T2:9 T3:204 | Median(IQR): 12 (7.8–25.7) | UC | 171 (80.3) | range:60–70 |
| SRT | Median (IQR):66 (61–70) | 1/340/163 | T2:63 T3:441 | Median(IQR): 11 (7.0–18.9) | UC | 212 (42) | range:60–70 | |
| Detti 2012 | ART | Mean ± SD:65.1 ± 7.3 | 44/77/82 |
T2:22 ≥T3:181 |
Mean ± SD: 0.10 ± 0.28 | Mean ± SD: 0.47 ± 1.73 | 101 (49.8) | Mean ± SD: 66.2 ± 4.1 |
| SRT | Mean ± SD:67.0 ± 6.0 | 25/26/53 | T2:23 ≥T3:81 | Mean ± SD: 0.85 ± 0.52 | Mean ± SD: 1.73 ± 3.19 | 24 (23.1) | Mean ± SD: 66.8 ± 4.1 | |
| Ost 2011 | ART | Median(range):63 (51–77) | 64(including 3 + 4)/25(including 4 + 3) |
T2:21 ≥T3:68 |
Median(range): 10.0 (3.0–47.9) | < 0.2 | 68 (76) | Median:74 |
| SRT | Median(range):64 (42–75) | 64(including 3 + 4)/25(including 4 + 3) |
T2:21 ≥T3:68 |
Median(range): 10.0 (3.5–148) | ≥0.2 | 59 (66) | Median:76 | |
| Trabulsi 2008 | ART | Median(range):62.0 (42–76) | 22/17/57 | ≥T3:96 | Median(range): 8.3 (1.1–65.9) | < 0.2 | 80 (83) | Median(range): 60 (50–70) |
| SRT | Median(range):63.0 (47–75) | 22/17/57 | ≥T3:96 | Median(range): 9.0 (1.7–39) | Median(range): 0.7 (0.2–2) | 80 (83) | Median(range): 64.8 (59–70) | |
| Tsien 2003 | ART | Median(range):63.0 (43.8–75.7) | 11/16/8 | ≥T3:36 | Median(range): 11.6 (1.1–99.6) | UC | 34 (89) | Median(range): 64.0 (59.4–69.0) |
| SRT | Median(range):64.2 (42.1–78.6) | 17/27/8 | ≥T3:38 | Median(range): 13.3 (0.2–120.0) | Median(range): 1.2 (0.2–18.4) | 27 (47) | Median(range): 65.0 (60.0–75.0) | |
| Taylor 2003 | ART | median:60 | 9/35/30 | ≤T2:27 ≥ T3:48 | Median:11 | Median:< 0.1 | 73 (96) | Median(range): 60 (51–70) |
| SRT | UC | 18/27/24 | ≤T2:12 ≥ T3:59 | UC | UC | UC | Median(range): 70 (60–78) | |
| Kalapurakal 2002 | ART | Overall median (range): 60 (48–78) | Overall 66(≤7)/10 | UC | Overall median(range):12.0 (4–82) | UC | overall 40 (53) | Median(range): 60 (60–65) |
| SRT | UC | Median(range): 0.5 (0.2–6.5) | Median(range): 65 (60–70) |
UC: unclear