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. 2019 Nov 9;7:175. doi: 10.1186/s40478-019-0833-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Correlation between the level of ALT activity, expressed as the percentage of radioactive signal with respect to the ALT signal recorded in genomic DNA from U2OS cells, designated to be 100 arbitrary units (AU), and patient age in anaplastic astrocytomas, AA (a, top and bottom left) and secondary glioblastomas multiform, GBM (b). Patient age was considered at the time of first surgery. a bottom right: According to statistical distribution, we arbitrarily defined two categories of anaplastic astrocytoma (AA) patients with C-circle score < or > 50 AU. This graphical representation also clearly shows the ALT intensity/patient age correlation