Table 1.

Clinical parameters and molecular analyses of the tumors

Tumor number anaplastic astrocytomas	p53	Ki67	age at first symptoms	TERT promoter	C-circles (arbitrary units)
3570	5%	7%	56	wt	20
4080	50%	10%	56	wt	6
4140	50%	70%	28	wt	82
4827	60%	5%	32	wt	55
5595	30%	12%	54	wt	91
6637	80%	10%	33	wt	87
4185	40%	15%	33	wt	80
3552	70%	10%	32	wt	21
4644	60%	5%	66	wt	31
3635	3%	15%	43	wt	19
3843	90%	10%	29	wt	31
3091	80%	7%	68	wt	10
4126	50%	15%	61	wt	7
4975	50%	7%	55	wt	10
3240	5%	15%	NA	wt	170
3402	negative	3%	38	wt	1
4031	50%	10%	47	wt	31
4878	negative	15%	24	wt	103
5815	negative	12%	45	wt	14
3462	60%	10%	40	wt	60
4951	60%	10%	43	wt	11
5261	60%	5%	38	wt	59
5489	10%	30%	48	C250T	69
5546	80%	10%	27	wt	99
5841	60%	10%	58	wt	34
5895	100%	5%	51	wt	19
6013	60%	6%	33	wt	16
6095	negative	8%	NA	wt	56
6658	60%	12%	33	wt	3
3558	100%	20%	39	wt	22
4056	50%	15%	29	wt	5
4289	90%	10%	28	wt	24
4572	90%	8%	42	wt	49
4840	75%	8%	34	wt	61
5238	80%	8%	55	wt	21
5744	50%	12%	34	wt	83
5987	80%	15%	35	wt	90
5443	80%	12%	61	wt	12
5448	50%	12%	29	C228T	37
5790	50%	12%	47	wt	18
5793	60%	15%	43	wt	35
5866	60%	15%	40	wt	91
6244	60%	20%	45	wt	22
6309	60%	12%	39	wt	102
4569	90%	15%	32	C250T	40
2944	70%	10%	57	wt	25
5022	negative	12%	66	wt	24
5725	80%	12%	53	wt	12
6011	80%	20%	39	wt	46
5974	80%	5%	34	wt	16
5003	30%	5%	33	C228T	109
3684	25%	7%	33	C228T	1
4106	negative	10%	31	wt	49
5593	60%	10%	34	wt	34
5594	80%	11%	59	wt	13
6654	60%	8%	52	wt	17
6742	40%	4%	48	wt	38
5510	35%	20%	28	C228T	45
5912	80%	12%	33	wt	0
5398	80%	12%	36	wt	21
Tumor number secondary GBM	p53	Ki67	patient age (years)	TERT promoter	C-circles
3942	80%	25%	37	wt	6
2592	40%	10%	69	wt	41
3077	60%	20%	25	wt	16
3007	80%	30%	31	wt	82
3297	30%	70%	59	wt	77
4034	30%	10%	58	wt	7
4115	80%	25%	55	wt	101
3845	80%	8%	32	wt	32
3928	negative	30%	41	wt	58
3933	negative	25%	32	wt	88
3992	40%	15%	34	wt	20
3959	90%	15%	26	wt	13
3019	100%	25%	29	wt	136
2835	20%	8%	37	wt	52
3316	40%	70%	24	wt	68
2695	60%	60%	30	wt	38
3359	100%	60%	41	wt	10
3451	40%	3%	61	wt	40
4068	60%	20%	NA	wt	44
4082	negative	12%	35	wt	35
4125	60%	25%	36	wt	6
4145	30%	12%	29	wt	29
4194	70%	10%	33	wt	34
4245	15%	12%	29	wt	24
4234	80%	20%	30	wt	22
4554	60%	10%	33	wt	24
4602	60%	12%	65	C250T	2
4711	20%	10%	57	wt	31
4706	80%	40%	39	wt	132
4707	90%	30%	40	wt	21
5007	60%	12%	53	wt	18
5014	100%	30%	62	wt	95
4918	60%	15%	36	wt	15
5067	95%	15%	33	wt	42
5246	80%	5%	36	wt	16
5248	80%	30%	44	wt	60
5160	60%	12%	67	wt	44
5137	50%	50%	32	wt	33
5152	95%	12%	72	wt	4
5169	60%	20%	36	C228T	16
5543	80%	10%	23	wt	12
5876	40%	10%	32	wt	0
5839	5%	12%	55	wt	26
5983	negative	25%	43	wt	57