Fig. 2.

Intrathecal injection of paclitaxel elicits mechanical allodynia via astrocyte signaling. a Schematic illustration showing the experimental conditions and behavioral tests. b, c Effect of intrathecal injection of low amount paclitaxel on mechanical and cold allodynia in male mice (*P < 0.05 compared to vehicle, ANOVA, n = 5 per group). BL baseline. d–f Effect of intrathecal (i.t.) administration of the astrocytic inhibitor L-α-AA (d), as well as MEK (e) and JNK (f) inhibitors on mechanical allodynia induced by i.t. injection of paclitaxel in male mice (*P < 0.05 compared to PBS solution, ANOVA, n = 5 per group). BL baseline