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. 2019 Nov 9;19:285. doi: 10.1186/s12935-019-1015-7

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — NHE1 overexpression promotes MMP3 secretion in MV3 cells. Supernatants of cell cultures were analyzed. a Gelatin degradation assays indicate slight MMP9 and strong pro-MMP9 activity under all conditions examined (NHE1 overexpression, mock control, NHE1 inhibition with cariporide (HOE642)), (N = 3). b Immunoblot analysis shows a strong secretion of MMP3 (~ 54 kDa) in NHE1 overexpressing cells which can be reduced by cariporide (HOE642) (N = 4)