Fig. 1.

Mice lacking expression of Sc5d and, thus, the ability to produce 7-DHC from lathosterol in skin show suppression of EAE by UV-NB. (A) The inability to generate 7-DHC (gray solid line) has no impact on the development of EAE in control mice (versus WT, black solid line). Sc5d knockout mice that lack the ability to generate previtamin D₃ upon UV exposure show similar suppression of disease with UV-NB (dashed gray line) versus WT (dashed black line). (B) Cumulative disease index (CDI) does not differ between WT and knockout control animals. The degree of overall disease suppression is similar between WT (black hatched bars) and knockout mice (gray hatched bars) exposed to UV-NB compared to their respective controls. (C) Disease incidence is reduced with UV-NB, regardless of the ability to produce 7-DHC upon UV-NB exposure. Data shown represent cumulative data from 2 independent studies. *P < 0.05 versus respective controls.