Fig. 2.

Mice lacking either the 1⍺-hydroxylase enzyme or the VDR show similar suppression of EAE with UV-NB compared to WT mice. WT mice show significant disease suppression when exposed to UV-NB (dashed black lines). (A) Cyp27B1 knockout mice, which are unable to produce the active metabolite 1,25(OH)D₃, show similar suppression of disease with UV-NB (dashed gray line) compared to WT controls (solid gray line). (B) VDR knockout mice, which lack the receptor for 1,25 dihydroxy vitamin D, show a similar degree of EAE suppression with UV-NB (dashed gray line) compared to WT controls (solid gray line). *P < 0.05 versus respective controls.