. Author manuscript; available in PMC: 2020 Nov 1.

Published in final edited form as: J Allergy Clin Immunol Pract. 2019 May 14;7(8):2624–2633.e2. doi: 10.1016/j.jaip.2019.04.043

Table 2.

Associations between single non-invasive Type-2 inflammatory markers and an acute visit for asthma by 12 months (primary outcome).

Age group	Predictor	% with outcome	Crude OR (95% CI)	Adjusted OR¹ (95% CI)	Sensitivity	Specificity
Children 5–11 years	Elevated blood eosinophils
	≥ 150 cells/microliter	40.4	2.68 (2.07, 3.46)^*	2.39 (1.83, 3.13)^*	0.848	0.312
	≥ 200 cells/microliter	40.4	1.81 (1.47, 2.22)^*	1.66 (1.33, 2.06)^*	0.707	0.437
	≥ 250 cells/microliter	41.1	1.74 (1.43, 2.12)^*	1.51 (1.23, 1.87)^*	0.627	0.509
	≥ 300 cells/microliter	39.8	1.42 (1.17, 1.73)^*	1.19 (0.97, 1.46)	0.510	0.578
	Elevated exhaled nitric oxide²	35.2	0.99 (0.80, 1.22)	0.97 (0.78, 1.22)	0.293	0.708
	Elevated serum IgE
	≥ 100 kU/L	35.7	1.06 (0.84, 1.35)	0.99 (0.77, 1.28)	0.777	0.246
	≥ 200 kU/L	35.5	1.00 (0.82, 1.23)	0.86 (0.69, 1.08)	0.648	0.360
	≥ 300 kU/L	35.8	1.04 (0.85, 1.26)	0.92 (0.75, 1.14)	0.547	0.465
	Aeroallergen sensitization
	Any sensitization	37.4	1.84 (1.37, 2.47)^*	1.65 (1.21, 2.25)^*	0.893	0.188
	Multiple sensitization	38.2	1.64 (1.30, 2.08)^*	1.49 (1.17, 1.91)^*	0.694	0.426
Adolescents 12–21 years	Elevated blood eosinophils
	≥ 150 cells/microliter	28.7	1.98 (1.54, 2.55)^*	1.50 (1.13, 1.98)^*	0.772	0.392
	≥ 200 cells/microliter	31.5	2.46 (1.93, 3.12)^*	1.82 (1.40, 2.36)^*	0.727	0.492
	≥ 250 cells/microliter	32.5	2.24 (1.79, 2.80)^*	1.61 (1.26, 2.07)^*	0.621	0.586
	≥ 300 cells/microliter	35.7	2.53 (2.03, 3.16)^*	2.04 (1.60, 2.60)^*	0.555	0.687
	Elevated exhaled nitric oxide²	31.3	1.59 (1.26, 2.00)^*	1.24 (0.95, 1.61)	0.354	0.757
	Elevated serum IgE
	≥ 100 kU/L	28.3	2.00 (1.54, 2.61)^*	1.43 (1.06, 1.92)^*	0.769	0.361
	≥ 200 kU/L	27.7	1.47 (1.17, 1.85)^*	1.04 (0.81, 1.35)	0.628	0.461
	≥ 300 kU/L	28.0	1.44 (1.16, 1.80)^*	1.07 (0.84, 1.37)	0.555	0.535
	Aeroallergen sensitization
	Any sensitization	29.3	4.69 (3.17, 6.93)^*	2.39 (1.54, 3.71)^*	0.928	0.263
	Multiple sensitization	30.8	4.06 (2.95, 5.58)^*	2.31 (1.63, 3.28)^*	0.730	0.438

p < 0.05

OR = odds ratio, CI = confidence interval

Adjusted for sex, ethnicity, race, household education level, tobacco smoke exposure, and ICS use.

Defined as ≥35 ppb for children 5–11 years and ≥50 ppb for adolescents 12–21 years