Clinical features of LRBA-deficient patients. The bars are depicted as percentages. The disease symptom clusters are indicated with different colors. Red bars show infections, blue bars denote lymphoproliferation, green bars demonstrate immune dysregulation, yellow bar shows failure to thrive, black bar indicates osteoporosis, brown bar represents clubbing, silver bar indicates cholelithasis, pink bar show deafness, light blue, purple, dark blue and light green bars indicate chronic glomerulonephritis, malignancy, pulmonary thromboembolism and cholecystitis, respectively. RTI, respiratory tract infection; SM, splenomegaly; HM, hepatomegaly; LAP, lymphadenopathy; ITP, immune thrombocytopenia; AIHA, autoimmune hemolytic anemia; T1DM, type 1 diabetes mellitus.