Table 3.
C-statistics (95% CI) with the addition of continuous hs-cTnT or NT-proBNP to basic model
| Base model | + hs-cTnT | + NT-proBNP | + hs-cTnT and NT-proBNP |
|
|---|---|---|---|---|
| Composite outcome | ||||
| C statistics (95% CI) | 0.691 (0.669, 0.713) | 0.694 (0.672, 0.716) | 0.704 (0.683, 0.726) | 0.704 (0.683, 0.726) |
| Difference (95%CI) | - | 0.003 (−0.002, 0.008) | 0.013 (0.005, 0.021) | 0.013 (0.005, 0.022) |
| All-cause mortality | ||||
| C statistics (95% CI) | 0.728 (0.699, 0.757) | 0.731 (0.702, 0.761) | 0.738 (0.708, 0.767) | 0.739 (0.709, 0.768) |
| Difference (95%CI) | - | 0.003 (−0.004, 0.010) | 0.010 (0.001, 0.018) | 0.011 (0.002, 0.020) |
| Cardiovascular mortality | ||||
| C statistics (95% CI) | 0.729 (0.685, 0.772) | 0.729 (0.685, 0.773) | 0.746 (0.702, 0.789) | 0.744 (0.702, 0.789) |
| Difference (95%CI) | - | 0.000 (−0.011, 0.011) | 0.017 (0.001, 0.033) | 0.015 (−0.001, 0.032) |
| Recurrent MI | ||||
| C statistics (95% CI) | 0.671 (0.621, 0.721) | 0.675 (0.624, 0.725) | 0.672 (0.622, 0.722) | 0.676 (0.625, 0.726) |
| Difference (95%CI) | - | 0.004 (−0.007, 0.014) | 0.001 (−0.005, 0.006) | 0.004 (−0.007, 0.015) |
| Heart failure | ||||
| C statistics (95% CI) | 0.706 (0.680, 0.733) | 0.709 (0.683, 0.735) | 0.723 (0.680, 0.749) | 0.723 (0.698, 0.749) |
| Difference (95%CI) | - | 0.003 (−0.004, 0.009) | 0.017 (0.007, 0.028) | 0.017 (0.006, 0.028) |
| Stroke | ||||
| C statistics (95% CI) | 0.707 (0.643, 0.770) | 0.706 (0.642, 0.769) | 0.721 (0.659, 0.784) | 0.722 (0.659, 0.785) |
| Difference (95%CI) | - | −0.001 (−0.004, 0.002) | 0.015 (−0.004, 0.033) | 0.015 (−0.003, 0.034) |
Base model included age at MI, female, race*field center, prior heart failure, hypertension, diabetes, prior stroke, coronary artery bypass graft, peripheral artery disease, chronic kidney disease, current smoking, and calendar year of MI (≥2005 vs. <2005), and elapsed time between premorbid biomarker measurements and incident MI.