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. 2019 Nov 6;12:9291–9302. doi: 10.2147/OTT.S229514

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© 2019 Zhai et al.

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The role of hsa-circ-0046600 in HCC migration. (A) SiCirc0046600 had a specific effect on hsa-circ-0046600, and the corresponding mRNA was not affected. (B) The migration rates of SK-HEP-1 cells were determined by a wound scratch assay. The migratory ability of the experimental group was lower than that of the control group. (C) Quantiﬁcation of relative migration in SK-HEP-1 cells transfected with NC, siCirc0046600-A, siCirc0046600-B. (D) The migration rates of HepG2 cells were determined by a wound scratch assay. The migratory ability of the experimental group was lower than that of the control group. (E) Quantiﬁcation of relative migration in HepG2 cells transfected with NC, siCirc0046600-A, siCirc0046600-B. (F) Western blot analysis showed that N-cadherin and HIF-1α expression was significantly reduced in the experimental group. (G, H) Quantiﬁcation of relative protein in HepG2 and SK-HEP-1 cells transfected with NC, siCirc0046600-A, siCirc0046600-B. Data are reported as the mean ± standard deviation. *P-value < 0.05, **P-value < 0.01, ***P-value < 0.001.