Figure 2.

Graphic representation of required criteria to establish safety of lipofilling following BCS. Criteria to determine safety of lipofilling following BCS included: (I) description of the interval between BCS and lipofilling; (II) time to follow-up from BCS of 6 years; (III) time to follow-up from lipofilling of 3 years; (IV) subgroup analysis focusing on ER, PR, Her-2; (V) presence of any comparison group at all; (VI) comparison group matched controls specifically for ER, PR, and Her-2; (VII) adequate powering. BCS, breast conservation surgery.