Table 1. Study design and rates of locoregional recurrence (LRR).

Study	Design	BCS + lipofilling (n)	BCS alone (n)	LRR BCS + lipofilling (%)	LRR BCS alone (%)
Biasio et al.	RCS	37	88	0	n/a
Biazus et al.	PCS	65	0	7.86	n/a
Brenelli et al.	PCS	59 patients (75 cases)	0	5.1*	n/a
Debald et al.	RCS	17	0	0	n/a
Gale et al.	RCC	35	64	5.7	3.1
Garcia et al.	PCS	37	0	0	n/a
Kahn et al.	PCS	32	39	0	0
Krastev et al.	RCC	139	150	0.72	4.7
Mazur et al.	PCC	7	28	3.7**	4.1**
Mestack et al.	RCC	32	45	0	4.4
Perez-Cano et al.	PCS	67	0	0	n/a
Petit, Botteri et al.	RCC	125	250	1.0	4.0
Petit, Lohsiriwat et al.	RCS	143 patients (170 cases)	0	0.8	n/a
Petit, Rietjens et al.	RCC	59	118	0.18	0.3
Rietjens et al.	PCS	77	0	0.01	n/a
Silva et al.	RCS	63	0	3.2	n/a
Silva et al.	PCC	58	124	1.7	2.4
Sorrentino et al.	PCC	54	444	6.4**	5.0**
Stumpf et al.	RCC	27	167	3.7	4.2

*, reported as % recurrence per patient enrolled; **, overall LRR, not stratified for only BCS (includes mastectomy). BCS, breast conservation surgery; RCS, retrospective case series; PCS, prospective case series; RCC, retrospective case control; PCC, prospective case control.