Fig. 2.

Kininogen depletion does not influence bacterial growth or dissemination during pneumonia-derived sepsis. Bacterial loads [colony-forming units (CFUs)] in the lung, blood, liver, and spleen 12 and 36 h after infection with K. pneumoniae via the airways in mice pretreated with Ctrl ASO or KNG ASO. Data were expressed as box-and-whisker diagrams (10-Log) of 8 mice/group at each time point. At 12 h the vast majority of cultures from blood, liver, and spleen were sterile, reflecting the initially localized infection. Differences between groups were not significant with Mann-Whitney U-test.