Fig. 3.

Kininogen depletion does not influence neutrophil influx but lowers myeloperoxidase (MPO) levels in lungs during pneumonia-derived sepsis. Ly6G (neutrophil) stainings of lung sections from mice before (A and B) and 12 (C and D) or 36 (E and F) h after infection with K. pneumoniae via the airways. A, C, and E are representative images from Ctrl ASO-treated mice; B, D, and F are from KNG ASO-treated mice. Original magnification ×4. G: percentage of Ly6G-positive area in lung analyzed with Image J. H: MPO levels in lung homogenates. Data are expressed as box-and-whisker diagrams showing interquartile ranges with medians of 8 mice/group at each time point. *P < 0.05 and **P < 0.01, Mann-Whitney U-test.