Fig. 5.

Effect of kininogen depletion on plasma biomarkers for endothelial activation, coagulation activation, and organ injury during pneumonia-derived sepsis. Endothelial (A and B) and coagulation activation (C) were investigated both before and 12 and 36 h after infection, whereas the biomarkers for liver (D and E) and general organ injury (F) were measured at 12 and 36 h after infection. Data are from mice pretreated with Ctrl or KNG ASO (8 mice/group at each time point) and presented as box-and-whisker plots showing interquartile ranges and medians. sE-selectin, soluble E-selectin; cVCAM-1, soluble vascular cell adhesion molecule-1; TATc, thrombin-antithrombin complexes; ALAT, alanine aminotransferase; ASAT, aspartate aminotransferase; LDH, lactate dehydrogenase. *P < 0.05, Mann-Whitney U-test.