Table 2.
Plasma cytokine and chemokine levels in noninfected and 12- and 36-h infected mice with Ctrl ASO or KNG ASO pretreatment
|
Time 0 |
Time 12 h |
Time 36 h |
||||
|---|---|---|---|---|---|---|
| Cytokines and Chemokines, pg/ml | Ctrl ASO | KNG ASO | Ctrl ASO | KNG ASO | Ctrl ASO | KNG ASO |
| IL-6 | ND | ND | 479 (384–908) | 368 (163–524) | 7,786 (3,294–15,780) | 5,492 (2,830–13,710) |
| TNF-α | 23 (ND–37.75) | 62 (7–75) | 68 (15–94) | 20 (1.6–44) | 921 (685–3,298) | 938 (622–2,163) |
| IL-10 | ND | ND | 4 (ND–19) | ND | 567 (313–1,038) | 300 (46–769) |
| MCP-1 | 1,058 (924–1,319) | 1,433 (1,317–2,118) | 1,307 (1,096–1,811) | 1,501 (1,201–1,612) | 9,804 (5,422–100,000) | 16,648 (8,209–100,000) |
| IFN-γ | 15 (14–20) | 15 (13–18) | 19 (17–22) | 14 (13–16) | 254 (65–2,109) | 343 (161–1,004) |
Values are medians (interquartile ranges). MCP-1, monocyte chemoattractant protein-1; IFN, interferon-γ; ND, not detectable, used for those groups if more than one-half was not detectable. The highest concentration for depicting the standard curve was 10,000 pg/ml. MCP-1 data were extrapolated until 100,000 pg/ml.